Estudios de biodisponibilidad


  1. Ichikawa S, Morifuji M, Ohara H, Matsumoto H, Takeuchi Y, Sato K. “Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate”. Int J Food Sci Nutr. 2010 Feb;61(1):52-60
  2. Iwai K, Hasegawa T, Taguchi Y, Morimatsu F, Sato K, Nakamura Y, Higashi A, Kido Y, Nakabo Y, Ohtsuki K. “Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates”. J Agric Food Chem. 2005 Aug 10;53(16):6531-6.
  3. Kawaguchi T1, Nanbu PN, Kurokawa M. “Distribution of prolylhydroxyproline and its metabolites after oral administration in rats”. Biol Pharm Bull. 2012; 35 (3):422-7.
  4. Oesser S., Adam M., Babel W. and Seifert J. “Oral Administration of 14C Labelled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL)”. American Society for Nutritional Sciences.1999:1891-1895
  5. Roberts P. R., Burney J.D., Black K. W. and Zaloga G.P. “Effect of Chain Length on Absorption of Biological Peptides from the Gastrointestinal Tract”. 1999; 60: 332-337
  6. Watanabe-Kamiyama M, Shimizu M, Kamiyama S, et al. “Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats”. J Agric Food Chem 2010; 58(2): 835-41.
  7. Zeijdner E.E. “Digestibility of collagen hydrolysate during passage through a dynamic gastric and small intestinal model (TIM-1) “. TNO Nutrition and food Research Report. 24 June 2002

Estudios a nivel articular

  1. Adam, M. “What effects do gelatin preparations have? Therapy of osteoarthritis” (in German). Therapiewoche 1991; 41: 2456-2461
  2. Arquer A., Pujol P. “Physical activity for elderly people – Effect of a food supplement on joint mobility”. Revista Española de Medicina de la Educación Física y el Deporte. 1996; 5 (3): 121 – 128
  3. Banzer W., Ziesing A., Dietmar A. “Results of a clinical surveillance on collagen hydrolysate consumption in arthritis” Medicines and Science in Sports & Exercise. 2006; 38 (5): S 438
  4. Bello A. E., Oesser S. “Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature”. Current Medical Research and Opinion. 2006; 22 (11): 2221- 2232.
  5. Benito P., Monfort J., Nacher M. “Effect of Hydrolyzed Collagen on human chondrocytes cultures”. Septiembre 2002.
  6. Benito-Ruiz P., Villacis R.A., Zurita L.A. et al. “A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort”. International Journal of Food Sciences and Nutrition 2009, 60 (S2): 99-113.
  7. Beuker F, Eck T, Rosenfeld J. “Biochemical and clinical examinations on the effects of regular applications of gelatine on degenerative damages of the motoric system”. Int J Sports Med. 1996; 17(suppl 1):S67-S70.
  8. Beuker F. “The Effect of Gelatin Administration in Cases of Chronic-Degenerative Joint Disease”. Lecture at the Symposium “Advances in the Therapy of Rheumatological Disease – What is Good and Effective?”, Heidelberg, 28th February 1998
  9. Carpenter R.L., Peel, J.B., Carpenter M.R., Lowndes J., Angelopoulos T.J., Rippe J.M., et al. “Effectiveness of a collagen hydrolysate-based supplement on joint pain, range of motion and muscle function in individuals with mild osteoarthritis of the knee: a randomized clinical trial”. Ann Rheum Dis 2005; Sup. 3: 1544-1545.
  10. Carpenter M.R., Carpenter R.L., McCarty S.M., Kline G., Angelopoulos T.J. et al. “Collagen Hydrolysate Supplementation Improve Symptoms in Patients with Severe Osteoarthritis”. Medicine & Science in Sports & Exercise. 2005; 37 (5) Suppl. May: 91-92
  11. Clark K. L., Sebastianelli W., Flechsenhar K. R. et al. “24- week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain”. Current Medical Research and Opinions 2008, 24 (5): 1485-1498.
  12. Flechsenhar K, Alf D. “Results of a postmarketing surveillance study of collagen hydrolysate CH-Alpha” [in German] Orthopadische Praxis 2005;41:486-494
  13. Götz B. “Well-nourished cartilage does not grind” (in German). Ärtzliche Praxis. 1982; 92: 3130-3134
  14. Kasper H. “Volkskrankheit Arthrose” Ernährungs-Umschau. 2003; 50 (7): 278-279
  15. Kasper H. “Die chondroprotektive Wirkung von Gelatine”. Med Welt. 2003 3: 47-49
  16. Koepff P., Müller A., Schrieber R., Turowski A. and Bräumer K. “Agentes para el tratamiento de artrosis”. Oficina Española de Patentes y Marcas nº ES 2 059 328 (27.01.1988). Traducción de Patente Europea 87110603.5.
  17. Krug E. “On supportive therapy for osteo- and chondropathy” [in German]. Ernährungsheilkunde. 1979;28:1-23.
  18. Kumar S, Sugihara F, Suzuki K, Inoue N, Venkateswarathirukumara S. “A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis” J Sci Food Agric. 2015 Mar 15;95(4):702-7.
  19. McAlindon TE, Nuite M, Krishnan N, Ruthazer R, Price LL, Burstein D, Griffith J, Flechsenhar K. Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial. Osteoarthritis Cartilage. 2011 Apr;19(4):399-405.
  20. Mc Carthey S.M., Carpenter M. R., Barrell M.M., Morrissey D.E., Jacobson E., Kline G., et al. “The effectiviness of gelatine supplementation treatment in individuals with symptoms of mild osteoarthritis”. American Academy of Family Physicians, Annual assembly, Dallas (TX) 2000
  21. Moskowitz, R. W. “Role of Collagen Hydrolysate in Bone and Joint Disease”. Seminars in Arthritis and Rheumatism. 2000; 30 (2): 87-9
  22. Nakatani S, Mano H, Sampei C, Shimizu J, Wada M. “Chondroprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage in vitro and in vivo”. Osteoarthritis Cartilage. 2009 Dec; 17(12):1620-7.
  23. Oesser S. and Seifert J. “Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen”. Cell Tissue Research. 2003; 311 (3): 393-399
  24. Oesser S., Haggenmüller D., Schulze, C.H. “Collagen hydrolysate modulates the extracellular matrix metabolism of human chondrocytes”. Rheum. Dis. 2006; 65 (suppl. II): 401
  25. Ribas Fernández JL, Molinero Pérez O. “Effects of gelatine hydrolysate in the prevention of athletic injuries”. Archivos de Medicina del Deporte. 1998; 15:277-282.
  26. Seeligmüller K, Happel HK. “Can a mixture of gelatin and L-cystine stimulate proteoglycan synthesis?” [in German]. 1989;39:3153-3157.
  27. Seeligmüller K. “Help and support for cartilage” [in German]. 1993;43:1810-1813.
  28. Trc T, Bohmova J. “Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA)”. Int Orthop.2011;35:341—8.
  29. Weh L., Bramstedt B. “Gelatine: Are there any Health Potential?”. Extracta orthopaedica, 1999; 5: 15-17
  30. Zuckley L., Angelopoulou, K.M. et al. “Collagen hydrolysate improves joint function in adults with mild symptoms of osteoarthritis of the Knee”. Medicine & Science in Sports & Exercise. 2004; 36 (5): 153-15

Estudios a nivel óseo

  1. Adam M., Spacek P., Hulejova H., Galianova A., Blahos J. “Postmenopausal osteoporosis. Treatment with calcitonine and a diet rich in cartilage proteins. Cas Lèk ces. 1996, 135: 74-8.
  2. Adam M., Eggersglüss B., Bräumer K. and Schrieber R. “Use of tasteless, Hydrolyzed Collagen and Agent containing the same”. United States Patent nº 5,948,766 (7.09.1999). 
  3. De Almeida Jackix E, Cúneo F, Amaya-Farfan J, de Assunção JV, Quintaes KD. “A food supplement of hydrolyzed collagen improves compositional and biodynamic characteristics of vertebrae in ovariectomized rats.” J Med Food. 2010 Dec; 13(6):1385-90
  4. Guillerminet F, Beaupied H, Fabien-Soulé V, Tomé D, Benhamou CL, Roux C, Blais A. “Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study”. 2010 Mar; 46(3):827-34.
  5. Guillerminet F, Fabien-Soulé V, Even PC, Tomé D, Benhamou CL, Roux C, Blais A“Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice”. Osteoporos Int. 2012 Jul; 23(7):1909-19.
  6.  Kim HK, Kim MG, Leem KH  “Osteogenic activity of collagen peptide via ERK/MAPK pathway mediated boosting of collagen synthesis and its therapeutic efficacy in osteoporotic bone by back-scattered electron imaging and microarchitecture analysis” Molecules 2013, 18, 15474-15489
  7.   Kim HK, Kim MG, Leem KH “Collagen hydrolysates increased osteogenic gene expressions via a MAPK signaling pathway in MG-63 human osteoblasts” Food Funct. 2014 Mar; 5(3): 573-8
  8. Koyama Y., Hirota A., Mori H., et al. “Ingestion of gelatin has differential effect on bone mineral density and body weight in protein undernutrition”. J Nutr Sci Vitaminol (Tokyo) 2001; 47(1):84–6.
  9. Leem KH1, Lee S, Jang A, Kim HK. “Porcine skin gelatin hydrolysate promotes longitudinal bone growth in adolescent rats.” J Med Food. 2013 May; 16(5): 447-53
  10. Liu J, Zhang B, Song S, Ma M, Si S, Wang Y, Xu B, Feng K, Wu J, Guo Y. (2014) “Bovine Collagen Peptides Compounds Promote the Proliferation and Differentiation of MC3T3-E1 Pre-Osteoblasts”. PLOS ONE 9(6): e99920.
  11. Liu J, Si S, Qin Y, Zhang B, Song S, Guo Y. “The effect of different molecular weight collagen peptides on MC3T3-E1 cells differentiation”. Biomed Mater Eng. 2015;26 Suppl 1:S2041-7.
  12. Lynch MP, Stein JL, Stein GS, Lian JB. “The influence of type I collagen on the development and maintenance of the osteoblast phenotype in primary and passaged rat calvarial osteoblasts: modification of expression of genes supporting cell growth, adhesion, and extracellular matrix mineralization”. Exp Cell Res. 1995 Jan;216(1):35-45.
  13. Mizuno M, Fujisawa R, Kuboki Y. “Type I collagen-induced osteoblastic differentiation of bone-marrow cells mediated by collagen-alpha2beta1 integrin interaction”. J Cell Physiol. 2000 Aug;184(2):207-13.
  14. Mizuno M, Kuboki Y. “Osteoblast-related gene expression of bone marrow cells during the osteoblastic differentiation induced by type I collagen”. J Biochem. 2001 Jan;129(1):133-8.
  15. Nomura, Y.; Oohashi, K., Watanabe, M. and Kasugai (2005). “Increase in bone mineral density through oral administration of shark gelatine to ovariectomized rats”. S Nutrition 21 (11-12): 1120–1126.
  16. Takada Y., Aoe S., Kato K., Toba Y., Yamamura J. “Collagen containing preparations for strengthening bone”. European Patent Application nº EP 0 798 001 A2 (1.10.1997)
  17. Takada Y., Aoe S., Kato K., Toba Y., Yamamura J. “Medicine drink food and feed having an action of strengthening bone”. United States Patent nº 6,344,437 B1 (5.02.2002).
  18. Wu J, Fujioka M, Sugimoto K, Mu G, Ishimi Y. “Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats”. J Bone Miner Metab. 2004;22(6):547-53.
  19. Yamada S, Nagaoka H, Terajima M, Tsuda N, Hayashi Y, Yamauchi M. “Effects of fish collagen peptides on collagen post-translational modifications and mineralization in an osteoblastic cell culture system”. Dent Mater J. 2013; 32(1):88-95.
  20. Takeda et al. “Hydrolyzed collagen intake increases bone mass of growing rats trained with running exercise” Journal of Internacional Society of Sports Nutrition 2013, 10:35 

Estudios a nivel dérmico

  1. Asserin J., Lati E., Shioya T., Prawitt J. (2015) “The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials” of Cosmetic Dermatology, 0, 1–11
  2. Beguin A. “A novel micronutrient supplement in skin aging: a randomized placebo-controlled double-blind study” Cosmet Dermatol 2005; 4(4): 277-84.
  3. Borumand M, Sibilla S. “Effects of a nutritional supplement containing collagen peptides on skin elasticity, hydration and wrinkles.” J Med Nutr Nutraceut 2015; 4:47-53
  4. Gimenez A, Conesa A, Benito P. “Effect of oral ingestion of Hydrolyzed Collagen on postmenopausal women skin wrinkle – A pilot study”. Octubre 2007
  5. Katayama K., Seyer J.M., Raghow R. and Kang A.H. “Regulation of extracellular matrix production by chemically synthesized subfragments of type I collagen carboxy propeptide”. Biochemistry 1991; 23; 30 (29): 7097-104
  6. Koyama Y., Sakashita A., Kuwaba K., Kusubata M. “Effects of oral ingestion of collagen peptide on the skin.” Fragr J. 2006; 34 (6): 82-85
  7. Matsuda, N., Koyama, Y-I., Hosaka, Y., Ueda, H., Watanabe, T., Araya, S., Irie, S. and Takehana, K. 2006. “Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis”. Journal of nutritional science and vitaminology. 52: 211-215.
  8. Matsumoto, H., Ohara, H., Ito, K., Nakamura, Y. and Takahashi, S. 2006. “Clinical effects of fish type I collagen hydrolysate on skin properties”. ITE Letters on batteries, new Technologies and medicine, 7(4):386-390.
  9. Morganti, P., Randazzo, S.D. and Bruno, C. (1988). “Oral treatment of skin dryness”. Cosmetics and Toiletries, 103: 77-80.
  10. Nishinimoto S., Hiura N. , Sato R. et al. “Effect of oral administration of gelatin and collagen peptides on the hydroxyproline content of rats’ skin”. Journal of the Japanese So. for food Science and Technology. 2002, 49 (3): 199-202.
  11. Ohara H., Ichikawa S., Matsumoto H., Akiyama M., Fujimoto N., Kobayashi T., Tarima S. “Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts” The Journal of Dermatology 2010; 37: 330-338
  12. Ohara H, Ito K, Iida H, Matsumoto H. “Improvement in the moisture content of the stratum corneum following 4 weeks of collagen hydrolysate ingestion“. Nippon Shokuhin Kogaku Kaishi 2009; 56: 137-45.
  13. Okawa T, Yamaguchi Y, Takada S, Sakai Y, Numata N, Nakamura F, Nagashima Y, Ikezawa Z, Aihara M. “Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin model”.
  14. Postlethwaite, A.E.; Seyer, J.M. and Kang, A.H. (1978). “Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides”. Proceedings of the National Academy of Sciences of the United States of America. 75(2): 871-875.
  15. Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. “Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis”. Skin Pharmacol Physiol. 2014; 27(3):113-9.
  16. Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. “Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study”. Skin Pharmacol Physiol 2014; 27(1): 47-55.
  17. Sibilla S, Godfrey M, Brewer S, Budh-Raja A and Genovese L “An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies” The Open Nutraceuticals Journal, 2015, 8, 29-42 29
  18. Schunck M., Zague V., Oesser S., and Proksch E. Dietary Supplementation with Specific Collagen Peptides has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology” J Med Food 18 (12) 2015, 1340–1348
  19. Shibuya S, Ozawa Y, Toda T, Watanabe K, Tometsuka C, Ogura T, Koyama Y & Shimizu T (2014) “Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice”, Bioscience, Biotechnology, and Biochemistry, 78:7, 1212-1220
  20. Shigemura, Y.; K Iwai, F Morimatsu, T Iwamoto, T Mori, C Oda, T Taira, EY Park, Y Nakamura and K Sato (2009). “Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin”. J Agric Food Chem 57 (2): 444–449
  21. Sumida, E., Hirota, A., Kuwaba, K., Kusubata, M., Koyama, Y., Araya, T. Irie, S. and Kasugai, S. 2004. “The effect of oral ingestion of collagen peptide on skin hydration and biochemical data of blood”. Journal of nutritional food, 7(3): 45-52
  22. Tanaka M, Koyama Y, Nomura Y. “Effects of collagen peptide ingestion on UV-B-induced skin damage”. Biosci Biotechnol Biochem. 2009, 73 (4): 930-932.
  23. Zague V, de Freitas V, da Costa Rosa M, de Castro GÁ, Jaeger RG, Machado-Santelli GM. “Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity”. J Med Food. 2011 Jun; 14(6):618-24.

Estudios sobre ligamentos y tendones

  1. Schunck, Oesser S. “Specific collagen peptides benefit the biosynthesis of matrix molecules of tendons and ligaments” Journal of the International Society of Sports Nutrition 2013, 10 (Suppl. 1):P23
  2. Weh L., Petau C. “Change in the Properties of Tissue through the Administration of Gelatine. A Biomechanica Pilot Study”. Extracta orthopaedica. 2001; 4: 12-16

Estudios sobre afecciones de salud específicas (fibromialgia, sarcopenia, úlceras de presión   )

  1. Gronemann ST, Ribel-Madsen S, Bartels EM, Danneskiold-Samsoe B, Bliddal H. 2004.”Collagen and muscle pathology in fibromyalgia patients”. 43: 27-31.
  2. Olson GB, Savage S, Olson J. 2000. “The effects of collagen hydrolysate on symptoms of chronic fibromyalgia and tempomandibular joint pain”. Cranio, 18(2): 135-41.
  3. Sprott H, Muller A, Heine H. 1998.“Collagen cross-links in fibromyalgia syndrome”. Rheumatol. 57 Suppl 2:52-5
  4. Vargas S. “A fibromyalgia pilot study” Mayo 2010
  5. Hays NP1, Kim H, Wells AM, Kajkenova O, Evans WJ. “Effects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older women”. J Am Diet Assoc. 2009 Jun;109(6):1082-7.
  6. Lee SK, Posthauer ME, Dorner B, Redovian V, Maloney MJ. “Pressure ulcer healing with a concentrated, fortified, collagen protein hydrolysate supplement: A randomized controlled trial”. Adv Skin Wound Care. 2006;19:92-96.

Estudios sobre aspectos generales de salud y nutrición

  1. Bodwell C. E. “Effect of Collagen on the Nutritional Value of Foods”. In “Collagen as Food”. Pearson M., Dutson T. R., Bailey a. J. Ed. Advances in Meat Research 4. AVI, Van Nostrand Reinold, New York, NY. 1987: 333-350
  2. Clark KL. “Nutritional considerations in joint health”. Clin Sports Med. 2007 Jan;26(1):101-18.
  3. Bone H. “Future directions in osteoporosis therapeutics”. Endocrinol Metab Clin North Am. 2012 Sep;41(3):655-61.
  4. Dybka K, Walczak P. 2009. “Collagen hydrolysates as a new diet supplement” Food Chemistry and Biotechnology, Vol. 73, nº 1058
  5. Eggersgluss B. “Gelatine Hydrolysate and its Health Aspects”. The European Food & Drink Review – Autumn 1999.
  6. Gougeon R. “The metabolic response to two very low energy diets (VLED) of differing amino acid composition during weight reduction”. Int J Obes Relat Metab Disord. 1992;16:1005-1012.
  7. Liu D, Nikoo M, Boran G, Zhou P, Regenstein JM. “Collagen and gelatin” Annu Rev Food Sci Technol. 2015;6:527-57.